Azumanga Daioh Puzzle Bobble (あずまんが大王 Puzzle Bobble Azumanga Daiō Puzzle Bobble) is a game based on the Azumanga Daioh anime and manga which was released by Taito Corporation as an arcade-only Puzzle Bobble spin-off on June 1, 2002. It was developed by MOSS for the Sega NAOMI GD-ROM arcade and distributed in Japan exclusively. It also has a two-player mode and the original voice actors from the Azumanga Daioh anime reprise their roles. It is controlled using one joystick and two buttons.
- This game takes place during second year after Episode 12.