The following characters are playable.
GameplayIn Azucola, the Azumanga Daioh characters face each other in matches to see who wins, and it is possible to play against the computer.
Similar to Columns, you can send attacks at your opponent, like making their pieces vanish or causing additional rows of useless blocks to show up from the bottom. The characters that are being used change their facial expressions depending on the outcome of the battle. Each character has two different outfits (summer and winter uniforms for the students). The images of the characters are based on illustrations known from manga chapter title pages.